Curriculum Vitae

Research Interest

The primary goal of my research is to understand the fundamental properties that govern signal transduction. In particular, I am interested in how dynamic cellular behavior (such as protection of the ischemic myocardium) can be attributed to hierarchical relationships within protein networks.

This overall goal is pursued in three main projects. First, we are examining the formation of multiprotein complexes at subcellular organelles to determine how changes in the constituents of these complexes alter phenotype. Second, we are studying the behavior of tyrosine kinase modules (such as Bmx) in protection of the ischemic heart and in the development of heart failure. Third, we are examining structure-function relationships in cardiac protein networks.

Repesentative Publications

Berhane BT, Zong C, Liem DA, Huang A, Le S, Edmondson RD, Jones RC, Qiao X, Whitelegge JP, Ping P, Vondriska TM. Cardiovascular-related proteins identified in the HUPO plasma proteome project pilot phase. Proteomics. 2005; 5:3520-3530.

Zhang J, Ping, P, Wang GW, Lu M, Pantaleon DM, Tang XL, Bolli R, Vondriska TM. Bmx, a member of the Tec family of non-receptor tyrosine kinases, is a novel participant in pharmacological cardioprotection. Am J Physiol. 2004;287:H2364-2366.

Vondriska TM, Ping P. Multiprotein signaling complexes and regulation of cardiac phenotype. J Mol Cell Cardiol 2003;35:1027-1033.

Edmondson RD, Vondriska TM, Biederman KJ, Zhang J, Allen DL, Zheng YT, Jones RC, Xiu JX, Cardwell EM, Pisano MR, Ping P. Protein kinase C e complexes contain metabolism and transcription/translation-related proteins: complementary electrophoretic separation techniques and LC/MS/MS. Mol Cell Proteomics 2002;1:421-433.

Vondriska TM, Klein JB, Ping P. Use of functional proteomics to investigate PKCe-mediated cardioprotection: the signaling module hypothesis. Am J Physiol 2001;280: H1434-H1441.

Vondriska TM, Zhang J, Song C, Tang XL, Cao X, Baines CP, Pass JM, Bolli R, Ping P. PKCe-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling. Circ Res 2001; 88:1306-1313.