Curriculum
Vitae
Research
Interest
The primary goal of
my research is to understand the fundamental properties that
govern signal transduction. In particular, I am interested in how
dynamic cellular behavior (such as protection of the ischemic
myocardium) can be attributed to hierarchical relationships within
protein networks.
This overall goal is
pursued in three main projects. First, we are examining the
formation of multiprotein complexes at subcellular organelles to
determine how changes in the constituents of these complexes alter
phenotype. Second, we are studying the behavior of tyrosine kinase
modules (such as Bmx) in protection of the ischemic heart and in the
development of heart failure. Third, we are examining
structure-function relationships in cardiac protein networks.
Repesentative
Publications
Berhane BT, Zong C,
Liem DA, Huang A, Le S, Edmondson RD, Jones RC, Qiao X, Whitelegge
JP, Ping P, Vondriska TM. Cardiovascular-related proteins
identified in the HUPO plasma proteome project pilot phase.
Proteomics. 2005; 5:3520-3530.
Zhang J, Ping, P,
Wang GW, Lu M, Pantaleon DM, Tang XL, Bolli R,
Vondriska TM. Bmx, a
member of the Tec family of non-receptor tyrosine kinases, is a
novel participant in pharmacological cardioprotection. Am J Physiol.
2004;287:H2364-2366.
Vondriska TM, Ping P. Multiprotein signaling complexes and regulation of cardiac
phenotype. J Mol Cell Cardiol 2003;35:1027-1033.
Edmondson RD,
Vondriska TM, Biederman KJ, Zhang J, Allen DL, Zheng YT, Jones RC,
Xiu JX, Cardwell EM, Pisano MR, Ping P. Protein kinase C e complexes
contain metabolism and transcription/translation-related proteins:
complementary electrophoretic separation techniques and LC/MS/MS.
Mol Cell Proteomics 2002;1:421-433.
Vondriska TM, Klein JB, Ping P. Use of functional proteomics to investigate PKCe-mediated
cardioprotection: the signaling module hypothesis. Am J Physiol
2001;280: H1434-H1441.
Vondriska TM, Zhang
J, Song C, Tang XL, Cao X, Baines CP, Pass JM, Bolli R, Ping P.
PKCe-Src modules direct signal transduction in nitric oxide-induced
cardioprotection: complex formation as a means for cardioprotective
signaling. Circ Res 2001; 88:1306-1313.
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