Curriculum Vitae

Research Summary

Cardiovascular physiology: the phenotypic assessment of mechanical function in whole heart using in vivo methodology, and in cells using biophysical and engineering approaches applied to normal and genetically altered rodent models.

Representative Publications

Delbridge, L.M.D., and K.P. Roos.  Optical methods to evaluate the contractile function of unloaded isolated cardiac myocytes.  J. Molec. Cell. Cardiol., 29:11-25, 1997.

Marro, M., O. Scremin, M.C. Jordan, F. Porro, K.P. Roos, S. Gajovic, F.E. Baralle, and A. F. Muro. Systolic hypertension in β-adducin deficient mice.  Hypertension. 36:449-453, 2000.

Jordan, M.C., B.D. Quednau, K.P. Roos, R.S. Ross, K.D. Philipson, S.B. Nicholas. Cyclosporin A regulates sodium-calcium exchanger (NCX1) gene expression in vitro and cardiac hypertrophy in NCX1 transgenic mice. N.Y. Acad. Sci. 976:259-267, 2002.

Warren, C.M., M.C. Jordan, K P. Roos, P.R. Krzesinski, and M.L. Greaser. Titin isoform expression in normal and hypertensive myocardium. Cardiovascular Research. 59:86-94, 2003.

Henderson, S.A., J.I. Goldhaber, J.M. So, T. Han, C. Motter, A. Ngo, C. Chantawansri, M.R. Ritter, M. Friedlander, D.A. Nicoll, J.S. Frank, M.C. Jordan, K.P. Roos, R.S. Ross, and K.D. Philipson.  Functional adult myocardium in the absence of Na+-Ca2+ exchange: Cardiac specific knockout of NCX1.  Circ. Res. 95:604-611, 2004.

MacLellan, W.R., H. Oh, P. Frenkel, M.C. Jordan, K.P. Roos, and M.D. Schneider. Overlapping roles of pocket proteins in the myocardium are unmasked by germline deletion of p130 plus heart-specific deletion of Rb. Molecular and Cellular Biology, 25:2486-2497, 2005.

Jordan, M.C., Y. Zheng, N. Rozengurt, S. Ryasantsev, K.P. Roos, E.F. Neufeld. Cardiac manifestations in the mouse model of mucopolysaccharidosis I. Molec. Genetics & Metab. (in press) 2005.

Wehling-Henricks, M., M.C. Jordan, K.P. Roos, J.G. Tidball. Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium. Human Molec. Genet. (in press), 2005.