Research Summary

Cardiovascular physiology: the phenotypic assessment of mechanical function in whole heart using in vivo methodology, and in cells using biophysical and engineering approaches applied to normal and genetically altered rodent models.

Representative Publications

Delbridge, L.M.D., and K P. Roos. Optical methods to evaluate the contractile function of unloaded isolated cardiac myocytes. J. Molec. Cell. Cardiol., 29:11-25, 1997.

Warren, C.M., M.C. Jordan, K P. Roos, P.R. Krzesinski, and M.L. Greaser. Titin isoform expression in normal and hypertensive myocardium. Cardiovascular Research. 59:86-94, 2003.

Henderson, S.A., J.I. Goldhaber, J.M. So, T. Han, C. Motter, A. Ngo, C. Chantawansri, M.R. Ritter, M. Friedlander, D.A. Nicoll, J.S. Frank, M.C. Jordan, K P. Roos, R.S. Ross, and K.D. Philipson. Functional adult myocardium in the absence of Na+-Ca2+ exchange: Cardiac specific knockout of NCX1.  Circ. Res. 95:604-611, 2004.

Wehling-Henricks, M., M.C. Jordan, K P. Roos, B. Deng, J.G. Tidball. Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium. Human Molec. Genet. 14: 1921-1933, 2005.

Jordan, M.C., Y. Zheng, N. Rozengurt, S. Ryasantsev, K P. Roos, E.F. Neufeld. Cardiac manifestations in the mouse model of mucopolysaccharidosis I. Molec. Genetics & Metab. 86:233-243, 2005.

Pott, C., X. Ren, D.X. Tran, M.J. Yang, S. Henderson, M.C. Jordan, K P. Roos, A. Garfinkel, K.D. Philipson, J.I. Goldhaber. Mechanisim of shortened action potential duration in Na+ - Ca2+ exchanger knockout mice. Am. J. Physiol - Cell Physiology, 292:968-C973, 2007.

K P. Roos, M.C. Jordan, M.C. Fishbein, M.R. Ritter, M. Friedlander, H.C. Chang, P. Rahgozar, T. Han, A.J. Garcia, W.R, MacLellan, R.S. Ross, K.D. Philipson. Hypertrophy and heart failure in mice overexpressing the sodium-calcium exchanger. J. Card. Failure, 13:318-329, 2007.

Lee, S., T.T. Chen, C.L. Barber, M.C. Jordan, J. Murdock, S. Desai, N. Ferrara, A. Nagy,
K P. Roos, M.L. Ireula-Arispe. Autocrine VEGF signaling is required for vascular homeostasis. Cell, 130:691-703, 2007.

Angelis, E. A.Garcia, S.S. Chan, K. Schenke-Layland, S. Ren, S.J. Goodfellow, M.C. Jordan, K P. Roos, R.J. White, and W. R. MacLellan. A cyclin D2BRb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium.
Circ. Res. 102: 1222-1229, 2008.

Schenke-Layland, K., B.M. Strem, M.C. Jordan, M.T. DeEmedio, M.H. Hedrick, K.P. Roos, J.K. Fraser, W.R.MacLellan. Adipose tissue-derived cells improve cardiac function following myocardial infarction. J. Surg. Res. 153: 217-223, 2009.

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