Research Summary
Cardiovascular
physiology: the phenotypic assessment of mechanical function in whole heart
using in vivo methodology, and in cells using biophysical and engineering
approaches applied to normal and genetically altered rodent models.
Representative Publications
Delbridge, L.M.D.,
and K P. Roos. Optical methods to evaluate
the contractile function of unloaded isolated cardiac myocytes. J. Molec. Cell.
Cardiol., 29:11-25, 1997.
Warren, C.M., M.C. Jordan, K P. Roos, P.R.
Krzesinski, and M.L. Greaser. Titin isoform expression in normal and
hypertensive myocardium. Cardiovascular Research. 59:86-94, 2003.
Henderson, S.A., J.I. Goldhaber, J.M. So, T. Han, C. Motter, A. Ngo, C.
Chantawansri, M.R. Ritter, M. Friedlander, D.A. Nicoll, J.S. Frank, M.C. Jordan,
K P. Roos, R.S. Ross, and K.D. Philipson. Functional adult myocardium in the
absence of Na+-Ca2+ exchange: Cardiac specific knockout of NCX1. Circ. Res.
95:604-611, 2004.
Wehling-Henricks, M., M.C. Jordan, K P. Roos, B. Deng, J.G. Tidball.
Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a
neuronal nitric oxide synthase transgene in the myocardium. Human Molec. Genet.
14: 1921-1933, 2005.
Jordan, M.C., Y. Zheng, N. Rozengurt, S. Ryasantsev, K P. Roos, E.F. Neufeld.
Cardiac manifestations in the mouse model of mucopolysaccharidosis I. Molec.
Genetics & Metab. 86:233-243, 2005.
Pott, C., X. Ren, D.X. Tran, M.J. Yang, S. Henderson, M.C. Jordan, K P. Roos, A.
Garfinkel, K.D. Philipson, J.I. Goldhaber. Mechanisim of shortened action
potential duration in Na+ - Ca2+ exchanger knockout mice. Am. J. Physiol - Cell
Physiology, 292:968-C973, 2007.
K P. Roos, M.C. Jordan, M.C. Fishbein, M.R. Ritter, M. Friedlander, H.C. Chang,
P. Rahgozar, T. Han, A.J. Garcia, W.R, MacLellan, R.S. Ross, K.D. Philipson.
Hypertrophy and heart failure in mice overexpressing the sodium-calcium
exchanger. J. Card. Failure, 13:318-329, 2007.
Lee, S., T.T. Chen, C.L. Barber, M.C. Jordan, J. Murdock, S. Desai, N. Ferrara,
A. Nagy,
K P. Roos, M.L. Ireula-Arispe. Autocrine VEGF signaling is required for vascular
homeostasis. Cell, 130:691-703, 2007.
Angelis, E. A.Garcia, S.S. Chan, K. Schenke-Layland, S. Ren, S.J. Goodfellow,
M.C. Jordan, K P. Roos, R.J. White, and W. R. MacLellan. A cyclin D2BRb pathway
regulates cardiac myocyte size and RNA polymerase III after biomechanical stress
in adult myocardium.
Circ. Res. 102: 1222-1229, 2008.
Schenke-Layland, K., B.M. Strem, M.C. Jordan, M.T. DeEmedio, M.H. Hedrick,
K.P.
Roos, J.K. Fraser, W.R.MacLellan. Adipose tissue-derived cells improve cardiac
function following myocardial infarction. J. Surg. Res. 153: 217-223, 2009.
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